Morest Lab Research

	Auditory system used to provide a structural basis for study of signal processing by specific types of neurons, as defined by their patterns of synaptic organization
	Criteria were developed which allow correlations of structure, electrophysiology, and neurochemistry of the cell types, thus providing insights into the mechanisms of signal processing
	Developmental studies on differentiation of neurons and synapses in the auditory system using microscopy, cell culture, and transplantation
	Recent development of a concept of the synaptic nest as a type of synaptic organization with high potential for plasticity and pathology
	Plastic changes in synaptic organization of the mature auditory pathways Directed differentiation of embryonic stem cells into cochlear precursors for transplantation as treatment of deafness

Reviews & Selected Papers

Morest, D.K. (1997) Structural basis for signal processing. Challenge of the synaptic nests. In: Acoustical Signal Processing in the Central Auditory System (ed J Syka), NY: Plenum, pp 19-32.

Bilak MM, Hossain WA, Morest DK (2003) Intracellular fibroblast growth factor (FGF-2) produces different effects than extracellular application on development of cochleo-vestibular ganglion cells in vitro. J Neurosci Res 71:629-647.

Josephson EM, Morest DK (2003) Synaptic nests lack glutamate transporters in the cochlear nucleus of the mouse. Synapse 49:29-46.

Morest DK, Silver J (2003) The precursors of neurons, neuroglia, and ependymal cells in the CNS: What are they? Where are they from? How do they get where they are going? Glia 43: 6-18.

Kim JJ, Gross J, Morest DK, Potashner SJ (2004) A quantitative study of degeneration and new growth of axons and synaptic endings in the chinchilla cochlear nucleus following acoustic overstimulation. J Neurosci Res 77:829-842.

Morest DK, Cotanche DA (2004) Regeneration of the inner ear as a model of neural plasticity. J Neurosci Res 78:455-460.

Yang Y, Lacas-Gervais S, Morest DK, Solimena M, Rasband MN (2004) Beta IV spectrins are essential for membrane stability and the molecular organization of nodes of Ranvier. J Neurosci 24:7230-7240.

Liu A, Chen B, Yankova M, Morest DK, Maryon E, Hand AR, Nonet ML, Wang Z-W (2005) Role of ryanodine receptors in synaptic release at the C. elegans neuromuscular junction. J Neurosci 25: 6745-6754.

Hossain WA, Antic SD, Yang Y, Rasband MN, Morest DK (2005) Where is the spike generator of the cochlear nerve? Voltage-gated sodium channels in the mouse cochlea. J Neurosci 25:6857B 6868.

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Last updated September 11, 2007